Two deadly crashes on Ontario highways have claimed the lives of seven teenagers, provincial police said after a driver in one of the collisions died in hospital on Wednesday.

The seven deaths come after two unrelated multiple-vehicle collisions on icy rural Ontario highways on Tuesday – one outside Parry Sound and another just east of Sudbury.

Ontario Provincial Police said three teenagers died and another three people were injured in a two-vehicle collision on Highway 17, east of Sudbury.

Police say a minivan carrying four occupants from the Renfrew area crossed the centre line at about 6 p.m., striking a Jeep with two people inside.

Two passengers in the van, Keegan Melville, 18, and Zabrina Rekowski, 19, were killed in the crash. The van's driver, Hillary Afelski, 19, died Wednesday afternoon after spending the night in hospital.

The fourth van occupant, Emily Olmstead, 19, and the two people in the Jeep, Walter Rancourt, 72, and Patricia Rancourt, 71, were taken to hospital with serious injuries.

Meanwhile, OPP say four teens died and two others remain in hospital after a multiple-vehicle collision on Highway 69 near Parry Sound, Tuesday afternoon.

Investigators say the driver of a Chevrolet Camaro lost control on the icy road and collided with an oncoming Honda Civic and Chevrolet Optra.

The two occupants of the Camaro, 18-year-old Jessica Chamberland and her 17-year-old cousin Alyssa McKeown, both of Barrie, died at the scene.

The pair's uncle said the two were best friends.

"They were always together, they did everything together," Rob Savard told CTV Toronto. "They were like sisters and she lost control and unfortunately, tragically, they both died."

Civic driver Torry McIntyre-Courville, 18, from Sudbury, also died at the scene while passenger Cole Howard, 19, also of Sudbury, later died in hospital.

Howard's friend said that the heavy metal drummer was a great guy with a sense of humour.

"He loved music, that was his life," Josh Crump said. "Over the past few years he's just improved so much."

Two other Civic passengers – Nicholas Bradley, 19 and Connor Kennedy, 14, remain in Toronto hospitals in critical condition.

The driver of the Optra, 58-year-old Josephine McKechnie, was treated for minor injuries and released on Tuesday.

Provincial police are saying that alcohol and speed are not factors in the crashes.

With files from CTV Toronto's Zuraidah Alman. Follow her on Twitter at @ZuraidahCTV.