Escobar drove in two runs with three hits and the Blue Jays defeated the New York Yankees 7-1 on Friday for their fifth victory in a row.
"He's one of our better hitters," manager John Farrell said. "We put him in that three-spot and he didn't try to do anything different with his overall approach at the plate."
It was the second win in a row for the Blue Jays (47-47) over the Yankees (53-37) since the all-star break and they were playing without Bautista who leads the major leagues with 31 homers.
He left Thursday's game in the fourth inning after twisting his right ankle sliding into third.
"To see the numbers of runs we were able to put up tonight in Jose's absence was very good to see," Farrell said.
Bautista continues to be day-to-day with the ankle injury. The Blue Jays hope the third baseman will return on Sunday but Tuesday against Seattle is more likely.
Brandon Morrow (6-4) allowed four hits and one run while striking out six in 6 2-3 innings and left to a standing ovation with two out in the seventh after a strong 112-pitch outing.
"I commanded the inside of the plate very well tonight," said Morrow, who has won four consecutive decisions.
Reliever Jason Frasor pitched the ninth, making his 452nd appearance as a Blue Jay to tie Duane Ward for the franchise record for games by a pitcher. Frasor allowed three hits in the inning but no runs.
Toronto scored six runs, five earned, against New York starter Freddy Garcia (7-7) who allowed seven hits in five innings.
The Blue Jays opened the scoring in the first inning. Eric Thames doubled with one out and scored on a single by Escobar.
"I think he relished the opportunity to hit in the three hole tonight," said Farrell.
"It doesn't matter where I hit in the lineup," said Escobar who was 3-for-4 with a walk. "I have my own plan, I'm not going to change my approach to the plate. I'm not going to try and hit homers because I'm hitting third or fourth.
"I'm going to be the same guy and that's why I feel comfortable hitting in any situation because I won't change my approach."
Thames was able to keep going around third when left-fielder Brett Gardner threw to second.
The Yankees tied it in the second when Eduardo Nunez hit a run-scoring single.
Morrow, who walked two batters in the first two innings, retired the next 13 batters after Nunez's hit before Nick Swisher singled in the sixth.
"It was just more consistent command within the strike zone," Farrell said. "I don't think he was ever wild."
"I was falling behind a little bit," Morrow said. "I lost a couple of guys and then I started commanding the fastball a lot better."
With Bautista sidelined, Edwin Encarnacion played third and made a spectacular play in the fourth inning on Russell Martin of Chelsea, Que. He dove to his left to grab the bouncer and threw from a sitting position to first for the out. The crowd cheered Encarnacion who is better known for his poor fielding.
"That's one of the best plays that's ever been made behind me," Morrow said.
"I thought we played excellent infield defence," Farrell said. "Edwin tonight, a credit to the continued work that he's done throughout the course of the year. He really came up big particularly on the diving play."
Encarnacion had the crowd cheering again in the bottom of the fourth when his one-out double scored Travis Snider who had doubled. Jose Molina's two-out single scored Encarnacion to put Toronto into a 3-1 lead.
The Blue Jays added three runs to the lead in the fifth that Thames started with his second double of the game despite limping out of the batter's box with a leg cramp. Escobar and Adam Lind walked to load the bases. Thames scored when Aaron Hill grounded to short to force Lind at second as the Yankees failed to turn the double play.
Thames said he was dehydrated from taking extra outfield work before batting practice but said he would be ready to play Saturday.
Hill then stole second before Snider hit a sacrifice fly to left to score Escobar. Hill and Encarnacion, who was walked intentionally, then caught the Yankees napping with a double steal and Hill came home on the play on catcher Martin's throwing error.
Escobar drove in a run in the eighth with his third hit of the game.
