No one was injured in Tuesday's incident, which occurred about 3:15 p.m.
Officers from 53 Division said some glass fell from the 32nd floor of the same building on Saturday.
Television images from the scene suggest the same balcony is responsible for both incidents.
On Saturday, the falling glass hit a structure over the entranceway.
Toronto has been plagued recently by glass falling off downtown buildings.
On Monday, glass from a broken balcony at a condominium at Bay and Grenville Streets struck a woman on the wrist, causing minor injuries.
It was the fifth time balcony glass has fallen from the two Murano condo buildings in the area. No one was injured in the four earlier cases.
The Festival Towers condominium above the Bell Lightbox at King Street West and John Street lost two panes of glass off balconies last month.
While no one suffered injuries in that case, reports suggested some glass shards ended up on the plates of diners outside on King Street restaurant patios.
