A serious multi-vehicle crash in Innisfil sent three children and three adults to hospital on Wednesday morning.

The crash took place on 9th Line, between Yonge Street and 10 Sideroad, at around 10:30 a.m.

According to South Simcoe Police, two victims are considered to be in critical condition. The man and woman, both in their late 20s or early 30s, were transported to Toronto-area trauma centres via air ambulance.

An eight-year-old girl was transported to hospital in serious condition. The remaining victims -- a man in his 50s, a teenaged boy and a two-year-old girl -- suffered “less serious” injuries and were treated in hospital.

Initial reports suggest the crash involved a pickup truck, a car and a mail carrier vehicle.

Sgt. Deborah Smith said it appears one vehicle crossed the centre line and struck another head-on. Some of the victims needed to be extricated from the wreckage by firefighters.

“At this point we don’t have any suspicions that alcohol was involved. As far as speed, we are not sure. Our traffic unit is investigating and that will be determined,” Smith told CTV News Barrie.

“We do have a couple of witnesses that did stand by and provided us with some information and if there are any witnesses out there, we would absolutely love to hear from them.”

Road closures are in place in the area.