BRAMPTON, Ont. - A man is in hospital in critical condition after a crash on Highway 410 in Brampton, west of Toronto.

Provincial police say the crash happened at about 10 a.m. Wednesday in the southbound lanes of Highway 410 at Queen Street.

Investigators say a Toronto man driving a Buick Rendezvous lost control of the vehicle for unknown reasons.

It rolled several times as it travelled across the centre median into the northbound lanes.

The man was transported by air ambulance to Sunnybrook Hospital while a female passenger was taken to Brampton Civic Hospital with serious injuries.

Anyone with information about the collision is asked to contact the Port Credit detachment of provincial police.