Ontario Provincial Police are investigating a serious crash Friday afternoon that left one man in critical condition in hospital.

Police said a Pontiac Sunfire was travelling eastbound on Hwy. 401 near Highway 25 in the left lane when he lost control of the vehicle and collided with a tractor-trailer in the centre lane.

The 24-year-old driver of the car from Toronto was taken to Hamilton General Hospital in critical condition.

All lanes of the highway were re-opened shortly before 5:00 p.m.