A pedestrian was fatally struck in Hamilton on Tuesday afternoon, shutting down eastbound Highway 403 for several hours.

The collision happened shortly before 4 p.m. along Highway 403 at the Aberdeen Avenue overpass, Ontario Provincial Police say.

A woman was struck by a transport truck, OPP Sgt. Kerry Schmidt said. 

The circumstances surrounding her death remain unclear he added, but "at this point there are no signs of foul play."

Hamilton police, fire and paramedics responded to the crash. The coroner's office has since taken over the investigation shutting down the roadway. 

Highway 403 was closed between Aberdeen Avenue and the Lincoln M. Alexander Parkway for five hours. 

The roadway reopened at 10 p.m.