Highway 401 eastbound lanes through Mississauga have reopened following a fatal early morning crash.

The eastbound collector lanes from Highway 410 to Dixie Road were closed Wednesday morning as police investigated the crash, which left one driver dead.

Ontario Provincial Police said a tractor-trailer was travelling in the collector lanes when it was hit by a car from behind.

The driver of the car was pronounced dead at the scene. The driver of the tractor-trailer was not injured.