A nighttime accident sent a Mississauga man to hospital with life-threatening injuries after he suffered a heart attack while driving on Hwy. 401.

Around 10 p.m. Saturday the man was in the westbound express lanes near Kipling Avenue when the attack occurred.

His vehicle crossed five lanes of traffic, striking two vehicles. The vehicle then struck and came to a stop on the cement barrier. Drivers in the other two vehicles were not injured in the incident.

Police told the Toronto Star that there was "a significant amount of damage" to the front of a minivan, indicating it was probably the first vehicle struck.

"It was lucky that traffic wasn't heavier," OPP Const David Woodford told the Star. "There were virtually no trucks on the road. It could've been a lot, lot worse."

The man who suffered the heart attack was rushed to Etobicoke General Hospital without vital signs. He was later revived.

On Sunday he was listed as being in serious condition.

The accident closed three westbound lanes of the highway for over five hours while police conducted an investigation into the crash.

With files from The Canadian Press