Five people have been injured in a multi-vehicle crash that prompted police to temporarily close Toronto-bound lanes on the Queen Elizabeth Way in Niagara-on-the-Lake.

Provincial police said the collision happened at about 9:10 a.m. when the driver of a Buick pulling a utility trailer stopped the car in a live lane and exited the vehicle.

The unexpected stop triggered a multi-car collision involving the vehicles following the Buick, said Ontario Provincial Police.

During the crash, police said a Toyota moved forward and pinned the Buick's driver against a vehicle.

Police said the 54-year-old male driver of the Buick sustained critical injuries in the collision. He was transported to Hamilton General Hospital by air ambulance.

Drivers in other vehicles as well as one passenger were also transported to hospital with minor injuries.

Toronto-bound lanes on the QEW at Glendale Avenue were closed for several hours as police investigated. They have since been reopened. 

Anyone who may have witnessed the collision is encouraged to call police at 905-356-1311.

With files from The Canadian Press