Police have re-opened Highway 401 after a multi-vehicle crash caused a diesel spill.

The highway reopened around 5:30 p.m.

The crash occurred on the highway just west of Guelph Line.

OPP Sgt. Kerry Schmidt said four vehicles and one transport truck were involved in the crash but that all the occupants escaped with minor injuries.

“All the injuries are minor but one of the vehicles was a transport truck which has lost a load of diesel from its tanks,” Schmidt said in a Periscope. “So we have a diesel spill all across the highway. We’re working on getting a cleanup crew to fix the situation and get the vehicles removed.”

Schmidt estimated that the closure would be in place for "four to six hours," stretching into the evening rush hour.

“You’re going to want to avoid that area and possibly get off at Highway 25 in advance of that so you don’t get tied up in that mess,” he told commuters at the time.